The Endocannabinoid system through the binding of receptors in the paraventricular nucleus of the hypothalamus which regulates the erectile function and sexual behaviour of males, improve sexual function in patients affected by conditions or symptoms such as depression, anxiety disorder and pain Both animal & human studies, reported a peripheral effect of Cannabis on ED, specifically on the corpus cavernasum where cannabinoid receptors are present Cannabis enhances the subjective experience of sexual intercourse while potentially contributing to ED in a dose-dependent manner.